Open Positions (We’re Hiring!)
The Wythe Lab at the University of Virginia School of Medicine favors a cross disciplinary approach to solving key problems in cardiovascular development. Rather than wed ourselves to a singular model system or technique, we attack biological questions from multiple fronts, using gold standard genetic models-such as the mouse, cutting edge imaging techniques, genome-wide analyses, and classical biochemistry.
We have funding and are actively recruiting for people to pursue projects in multiple areas (again, from multiple angles), but are currently seeking expertise in developmental biology (zebrafish or mouse), molecular profiling methods (particularly genomics and proteomics), bioinformatics, and imaging. Our efforts center around the goal of elucidating the key transcriptional and molecular nodes that establish and maintain a functional cardiovascular system.
UVA School of Medicine (an equal opportunity employer) is located in Charlottesville, Virginia. Charlottesville is home to an excellent research environment and medical school and a world class undergraduate institution, and in close proximity to the beauty of Shenandoah National Park and only a few hours from Washington, D.C.
Currently we are looking for an RT I, and RTII:
Postdoctoral Fellowship in Vascular Biology
If you are passionate about research, creative, and ready to tackle difficult (but essential) problems in cardiovascular biology, and interested in joining our group, please email a single PDF containing:
1) Your CV (no biosketches or resumes, please)
2) A cover letter explaining your interest in our work (and how you would fit into the group)
3) A list of two to four references and their contact information.
Or click here (and search “wythe”)
Graduate Students
The Wythe Lab accepts rotation students from the following graduate programs associated with the Biomedical Sciences Program (BIMS) at UVA:
Neuroscience
Cell and Developmental Biology
If you are in a graduate program at the University of Virginia School of Medicine other than these two, but interested in our research, send me an email. I am sure we can figure something out!
Undergraduate Students
If your institution offers academic credit (such as available at the University of Virginia), or a work-study program, we currently have openings for committed undergraduate students to work on projects that are focused on developing core skills and experience in molecular biology, genetics and development. Students with non-traditional biological research backgrounds (engineering, chemistry, computer programming, bioinformatics) are also encouraged to apply, as we will find a niche for your unique talents (while ensuring that you obtain and master essential wet lab skills, if that is of interest). We are seeking students that can commit to 3-4 afternoons (or mornings) a week during the school year, then work full-time during the summers (paid, 40h/week). Topic areas include:
-MOLECULAR GENETICS
Engineer and validate novel genetically modified mouse and zebrafish models to understand blood vessel and heart development during embryogenesis.
-DEVELOPMENT & DISEASE
Use immunohistochemical staining, live imaging, and cutting edge microscopy to study cell-lineage relationships in the developing mouse and zebrafish embryo.
Contact me at: jwythe AT virginia.edu
What we study:
Located at The University of Virginia School of Medicine in Charlottesville, Virginia, our lab studies the transcriptional mechanisms that guide endothelial cell differentiation into distinct cell types, such as arteries and veins, as well as how these processes are deranged in diseases such as brain arteriovenous malformations. Additionally, we study how blood vessel growth impacts brain-centric diseases, such as glioma.
Brain Arteriovenous Malformations
Glioma
Transcriptional Regulation of Endothelial Differentiation
Cardiac Patterning and Development
Recent Manuscripts
Meet the Lab!
